实用医学杂志 ›› 2021, Vol. 37 ›› Issue (15): 1939-1943.doi: 10.3969/j.issn.1006⁃5725.2021.15.006

• 临床研究 • 上一篇    下一篇

全麻复合区域阻滞对肝癌开腹手术患者镇痛效应和术后康复的影响

王韶双, 周艳楠, 阳婷婷, 严军, 董麦娟, 王强    

  1. 西安交通大学第一附属医院麻醉科(西安 710061)

  • 出版日期:2021-08-10 发布日期:2021-08-10
  • 通讯作者: 王强 E⁃mail:dr.wangqiang@139.com
  • 基金资助:

    国家自然科学基金项目(编号:81974540);陕西省中医药管理局项目(编号:zyjzdyjs⁃16);院级临床研究计划项目(编号:XJY⁃FY⁃2019W9)

Effect of general anesthesia combined with regional block on analgesia and postoperative rehabilitation in liver cancer patients undergoing laparotomy

Effect of general anesthesia combined with regional block on analgesia and postoperative rehabilitation in
liver cancer patients undergoing laparotomy

WANG Shaoshuang,ZHOU Yannan,YANG Tingting,YAN Jun,DONG Maijuan,WANG Qiang.   

  1. Department of Anesthesiologythe First Affiliated Hospital of Xi′an Jiaotong UniversityXi′an 710061China
  • Online:2021-08-10 Published:2021-08-10
  • Contact: WANG Qiang E⁃mail:dr.wangqiang@139.com

摘要:

目的 探讨以区域阻滞为基础的多模式镇痛对肝癌开腹手术患者术后康复的影响。 方法 选取西安交通大学第一附属医院 2019 6 月至 2020 5 月择期行肝癌开腹手术的患者 80 例为研 究对象,将患者随机分为区域阻滞组(R 组)和对照组(C 组)。比较两组患者的苏醒时间,苏醒即刻和术后 24、48 h 的数字模拟疼痛评分(NRS 评分),镇痛药用量和术后恶心呕吐的发生率,术后血浆 TNF⁃α、IL⁃6 肝功能指标的变化,术后恢复质量 QoR⁃15 评分,术后住院时间。结果 R 组患者的苏醒时间较 C 组显著缩短(P > 0.01),苏醒即刻和术后 24 h 内的 NRS 评分显著低于 C 组(均 P < 0.05);R 组术后镇痛药的使用量 显著低于 C 组(P < 0.01),术后 24 h 恶心呕吐的发生率低于 C 组(P < 0.05);R 组术后 T1、T2 时间点上 TNF⁃ α IL⁃6 水平明显低于 C 组(P < 0.05);R 组患者术后谷丙转氨酶、总胆红素和白蛋白水平低于 C 组(P < 0.05),QoR⁃15 评分高于 C 组(P < 0.05),术后住院时间缩短(P < 0.05)。结论 全麻复合以区域阻滞为基 础的多模式镇痛方案能够完善镇痛效果,减少不良反应,并有效抑制炎性因子,改善肝癌开腹手术患者的术后早期镇痛状况,减少住院时间,值得在临床推广应用。

关键词:

全身麻醉,  , 区域阻滞,  , 多模式镇痛,  , 肝癌,  , 术后康复

Abstract:

Objective To investigate the effect of multimodal analgesia based on regional block on postop⁃ erative rehabilitation in liver cancer patients with undergoing laparotomy. Methods From June 2019 to May 2020 80 patients undergoing laparotomy for liver cancer in our hospital were selected. The patients were randomly divid⁃ ed into regional block group(group R)and control group(group C). The time of awakening and the digital analog pain score(NRS score),the dosage of analgesics and the incidence of postoperative nausea and vomiting(PONV were compared between the two groups at the moment of awakening,24 h and 48 h after operation. The changes of plasma TNF ⁃α,IL ⁃6 and liver function index,QoR ⁃15 score of postoperative recovery quality and postoperative hospital stay were recorded. Results The time of awakening in group R was significantly shorter than that in group C(P>0.01),and the NRS score immediately after awakening and within 24 h after operation in group R was sig⁃ nificantly lower than that in group C(all P<0.05). The use of postoperative analgesics in group R was significant⁃ ly lower than that in group C,and the incidence of PONV at 24 h after operation in group R was significantly lower than that in group C(P<0.05). The levels of TNF⁃an and IL⁃6 at T1 and T2 in group R were significantly lower than those in group C(P<0.05). The levels of ALT,TBIL and ALB in group R were lower than those in group C and the QoR⁃15 score was higher than that in group C. the postoperative hospital stay in group R was shorter than that in group C(P<0.05). Conclusion The multimode analgesia scheme of general anesthesia combined with re⁃ gional block could improve the analgesic effect,reduce adverse reactions,effectively inhibit inflammatory factors improve early analgesic effect of patients with liver cancer after laparotomy,and reduce hospital stay,which is wor⁃ thy of clinical application.

Key words:

general anesthesia, regional block, multimodal analgesia, liver cancer, postoperative rehabilitation